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the first two groups were prepared with unilateral 6-OHDA lesions and members of the first group was treated with MM-201 in DMSO 100 1: 8 8ml (0.5 mg/kg, i.p.) Members of Group 2 were treated with sterile DMSO 100 :PBS 8ml equivalent volumes to the weights

Additionally, we explored various substituents on the phenyl group of phenylalanine ( 9a to 9r ) as well as synthesized constrained phenylalanine analogues ( 9s to 9u )

FIGURE 6 FIGURE 7 4 Discussion We developed an LC/MS/MS method to quantitate the concentration of 7,8-DHF in neonatal mouse plasma and brain

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It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat