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( A , B ) Myocardial infarction (one isoprenaline challenge) and re-infarction (two isopre- naline subsequent challenges) in isoprenaline-treated rats (75 mg/kg sc (gray bars), 150 mg/kg sc (white bars))

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found that anti-PD-1, alone or in combination with anti-CTLA-4, failed to inhibit tumor growth in mice receiving a standard diet, whereas KD implementation, or oral administration of 3-hydroxybutyrate (3-HB), a principal KB generated in the KD, reestablished therapeutic responses