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Many of these placebo-controlled studies have demonstrated that folic acid supplementation improved symptoms in severely depressed patients, elderly depressed and demented patients, and those with major acute depression or schizophrenia, particularly in individuals with RBC folate levels below 453 nmol/L (46)

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Key accelerators of this breakdown include: Neuroinflammation: Cytokines from Lyme, Long COVID, or concussion damage synaptic connections.[5] Mitochondrial dysfunction: Energy factories in cells fail, starving muscles and brain of ATP.[6] Disrupted proprioception: The body loses its internal GPS, leading to imbalance and falls.[7] Sympathetic overdrive: Chronic fight-or-flight traps patients in pain/fatigue cycles.[8] Muscle atrophy: Inactivity after injury or illness causes rapid loss of strength and stability.[9] These create a vicious feedback loop