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For prostanoid generation, both COX-1, which is constitutively expressed by most cells, and COX-2, an inducible isoform upregulated by inflammatory mediators such as lipopolysaccharide, IL-1, IL-6, or tumor necrosis factor- (TNF-), convert AA into prostaglandin endoperoxides (PGs), such as prostaglandin G 2 (PGG 2 ) (Ramsay et al., 2003

To target acne opt for: Retinoids + Anti-Bacterial agents like Benzoyl Peroxide or Clarifying Botanicals Both Benzoyl Peroxide and retinoids are great for effective acne-fighting ingredients, but when used improperly, it will likely increase skin irritation

Kuang, W

& Kondratov, R

irritans could be a biomarker for oxidative stress induced by zinc ions