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Michel P, Pandya AG

Reactive astrocytes with reduced function of glutamate transporters in the App(NL-G-F) knock-in mice

While the peak for GSH (2.98 min) gradually decreased, the signal corresponding to GSSG increased (4.37 min), indicative of the expected chemical transformation (Fig

identified eight novel potential GPX4 activators and determined that compound 1d4 is the most potent allosteric activator of GPX4, effectively inhibiting ferroptosis in HT-1080 fibrosarcoma cells [328]