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However, these preclinical findings do not establish safety for use during human pregnancy, as species differences in placental transfer and fetal metabolism may exist

Also, NADPH oxidases can also generate ROS from other enzyme systems [57]

These superoxide radicals (O 2 ) come from NADPH oxidase (NOX) and the mitochondrial electron transport chain (ETC).Mechanistically, nonenzymatic lipid peroxidation starts when OH derived from the Fenton reaction extracts hydrogen atoms from the double-bonded carbon atoms of PUFAs, forming phospholipid radicals (PL ) with a carbon-centered structure