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Additional well-designed clinical studies are required to determine the long-term biological significance and potential translational applications of NNMT inhibition in humans

Treated animals also showed a significant reduction in the degeneration of Purkinje cells and CA1 hippocampal neurons and a reduction in the GFAP-positive cells in the corpus callosum

Additionally, the decreasing levels of vitreous VEGF-A after 12 weeks indicate the sustained inhibitory effect of this novel approach compared to current treatments