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Trxs and Grxs are thiol-disulfide oxidoreductases, whereas Prxs mainly reduce peroxides

J Clin Invest 105:16311639

Biochem J 1994;297(Pt 1):137-43

Lipidomics: techniques, applications, and outcomes related to biomedical sciences

These lead compounds have drug-like properties with acceptable pharmacokinetic profiles for oral route due to their predictions of high intestinal absorption, metabolism in the liver, drug distribution into the brain, and low excretion