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In digestive gastric ulcers, MEL promotes angiogenesis (222, 223), which accelerates healing, while in tissue hypoxia, such as age-related or in cancer, it inhibits neovascularization through inhibitory effects on HIF-1, HIF-1, VEGF and sphingosine kinase 1 (SPHK1) (224-227)

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0.1% RGN-259 (Thymosin 4) Ophthalmic Solution Promotes Healing and Improves Comfort in Neurotrophic Keratopathy Patients in a Randomized, Placebo-Controlled, Double-Masked Phase III Clinical Trial

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