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detected the methylation status of the gene promoters of 10 negative regulators of the Wnt/-catenin signalling pathway in 125 groups of colon cancer and adjacent tissue samples

Mechanistic investigations in the field have traditionally focused on single components, such as oocyte mitochondrial dysfunction [11, 12], local microenvironmental alterations [13,14,15], or epigenetic abnormalities [16,17,18]

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