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GSH also plays a critical role in many other biological processes, such as protein and DNA synthesis, and amino acids transport as well as protection of cells against oxidation

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Patients with G6PD deficiency show decreased insulin secretion ( Figure 3 The Role of the PPP in Chronic Diabetic Complications Diabetes can lead to diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, diabetic macroangiopathy and other chronic complications

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nevertheless, it may have a strong genetic component as demonstrated by the evidence that it occurs more often in certain families compared with the general population (Ckaa and Strosznajder 2010)

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