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Dog RBC were in vivo biotinylated and revealed during survival signs of an accelerated aging in so far as a classical cell age parameter, the ratio of the band 4.1a/4.1b content had reached its maximum (full deamidation) in the biotinylated RBC portion long before the biotinylated RBC had reached their full survival time (Rettig et al., 1999)

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Because these two proteins largely determine the mechanical behavior of skin its resistance to stretching and its ability to recoil the practical implication for GHK-Cu skin research is direct and measurable

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