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Although T RM cells play a vital role in protecting the immune system from pathogens, dysregulation of these cells can result in excessive inflammation and tissue damage in IBD

In addition, some lipids, such as phosphatidyl inositol, are the anchoring molecules to get proteins permanently associated to membranes, usually to the non-cytosolic hemilayer

Excessive extracellular glutamate inhibits system Xc , reducing cystine uptake and depleting GSH, thereby promoting ferroptosis

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[195] [212] This internalization is mediated by RhoA activation and its downstream effector ROCK, a process that is TAAR1-dependent