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At the mechanistic level, environmental pollutants first increase intestinal permeability, allowing bacteria and their products to cross the intestinal barrier and activate the immune system, triggering chronic inflammation [230, 231]

the hexane has an activity of 94.25% and methanol 87.33% at a concentration of 125 g/mL compared with BHT 43.22% as a control

Brain-first versus gut-first Parkinsons disease: a hypothesis

Research on germ-free mice and mice that were administered broad-spectrum antibiotics has demonstrated that the gut microbiota has an impact on intestinal immunity, thereby influencing both systemic and local immune reactions within the organism (Fung, 2020)

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