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Psychiatry 45 (3), 280285

In conclusion, TMAO orchestrates immune dysregulation in IBD through PERK-mediated ERS, NF-B activation, and NLRP3 inflammasome signaling

A dysregulated gut microbiome can lead to increased intestinal permeability (often called leaky gut'), which allows particles to enter the bloodstream and potentially trigger autoimmune responses, including those targeting the thyroid gland