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The activity of NRF2 is mediated by the KEAP1/CUL3/RBX1/E3 ubiquitin ligase complex [65]

doi:10.1016/j.freeradbiomed.2017.04.362 213

First, it is essential to unravel in depth the causal association and temporal sequence between ferroptosis and neurodegeneration, as well as to explore cell type-specific roles of iron accumulation and ferroptosis across various neural populations