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Caution all patients that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope [see Warnings and Precautions (5.2)]

On the contrary, the glutamate refilling rate monitored by glutamate uncaging experiments clearly shows similar biphasic dependence on cytosolic Cl concentrations with maximum glutamate transport at 30 mM (Hori and Takahashi, concentrations on the kinetics of glutamate transport and the magnitude of steady-state glutamate content, at least within the measured time frame, differ among Cl concentrations (Hori and Takahashi, , as suggested by biochemical analysis (Hartinger and Jahn, 1996)

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