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A practical evaluation may include CMP, creatinine and estimated GFR, serum bicarbonate/CO, electrolytes, glucose, hydration status, homocysteine, SAM, SAH, methionine and adenosine, together with clinical review of diet, kidney function, gastrointestinal health, inflammation and toxic exposure

third, developing cell-free therapeutic strategies based on the MSC secretome or extracellular vesicles

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Indeed, antiangiogenic drugs (AADs) by blocking tumor-derived factors demonstrate clinical benefits in human cancer patients 3,5

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