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SU11274, another ATP-competitive c-MET selective inhibitor, blocked the constitutive phosphorylation of c-MET and downstream kinases and induced G2/M cell cycle arrest and significantly suppressed cell growth in a dose-dependent manner [42]

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The researchers found that the estimated mean change in hemoglobin A1c (HbA1c) after 40 weeks was 1.8, 1.5, and 0.1 percentage points for cagrilintide-semaglutide 2.4 mg each, 1.0 mg each, and placebo, respectively

Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-nave patients with type 2 diabetes (SUSTAIN 4): a randomized, open-label, parallel-group, multicentre, multinational, phase 3a trial