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AOD-9604 also appears in cartilage repair research (originally investigated for osteoarthritis before pivoting to obesity), because the hGH fragment retains some regenerative signaling without the proliferative risks of full hGH

ATTAIN-2 (NCT05872620) This trial evaluated orforglipron in adults with obesity or overweight who also had type 2 diabetes, a critically important subpopulation given the high co-prevalence of these conditions

The role of NNMT in gluconeogenesis was further elucidated by Hong et al

For those targeting specific problem areas, understanding peptides for visceral fat loss provides additional context

AOD-9604 Regulatory Status As of June 2026, AOD-9604 is not FDA-approved for any therapeutic use