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Nat Rev Endocrinol 9 , 346356 (2013)

Report any new symptoms of fatigue, malaise, low-grade fever, and joint aches

We have also assessed the quality of stratified results reporting in clinical trials registered at ClinicalTrials.gov with at least one site in the United States, with annual reporting by year of primary completion shown in Figures B-10a and B-10b (stratified by funder as reported by ClinicalTrials.gov, and the difference indicated between all phases and just Phase 3 [commonly registrational] trials)