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In the IMPACT-TWIN system, the target POI sequence is cloned between two mini-inteins, where the vector is designed to produce a POI with a specific intein fused to either its N or C-terminus

If mitochondrial function is reduced with age, then tissue decline and susceptibility to degenerative disease become inevitable

If you are low or deficient in B12, restoring healthy levels may improve fatigue and energy over time

These results are consistent with animal models of CRS in which tumor-infiltrating macrophages have been identified as a major source of IL-6 (32, 33)