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The most common adverse reactions (incidence 20%) of pemetrexed, when administered in combination with pembrolizumab and platinum chemotherapy, are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia

Megadosing by doing frequent injections when you dont actually need it can lead to side effects like itchy rash, anxiety, and rapid heartbeat

Shrimp JH, Hu J, Dong M, Wang BS, MacDonald R, Jiang H, et al

Hydroxocobalamin has been found to be more effective than cyanocobalamin in treating symptomatic conditions when administered by injection, although Carmel recommends cycling between the two

Estimating the mean and variance from the median, range, and the size of a sample