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Shifting this metabolic balance toward ketometabolism is thought to reduce the reliance on anaerobic metabolic processes that drive oxidative stress [92]

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Despite such a likely connection, only one study to date has assessed differences in markers of oxidative damage in children affected with konzo, where increased levels of 8,12-iso-iPF2-VI isoprostane in affected children was associated with deficits in neurocognition, but not deficits in motor impairment 3

Hepatic Clearance of Drugs Nonrenal drug elimination is assumed to be due primarily to biotransformation (hepatic metabolism) and biliary excretion