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Metabolite-targeted interventions (such as probiotics, dietary modulation, and engineered microbes) show synergistic potential with ICIs, but require resolution of causal inference limitations, interindividual variability, tumor-context specificity, and dose optimization

Similarly, metabolic engineering of Escherichia coli Nissle 1917 (EcN-TRP), combined with double-layer microcapsule delivery, achieves colon targeting and elevates local levels of immunomodulatory indole metabolites (e.g., indole-3-propionic acid) (2024)

Nociceptive Pain: What It Is, Causes, Treatment & Types

Ex vivo expanded regulatory T cells CD4(+)CD25(+)FoxP3(+)CD127(Low) develop strong immunosuppressive activity in patients with remitting-relapsing multiple sclerosis

Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis