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In the same way, neratinib, a strong and permanent inhibitor of pantyrosine kinase, encourages ferroptosis and hinders brain metastasis in a new model of natural human epidermal growth factor receptor 2-positive breast cancer spread [38]

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Thus, experiments with ovariectomized (OVX) rats have shown a reduction in the anti-oxidant activity of superoxide dismutase (SOD) in the hippocampus, a process that contrasts with an increase in the pro-oxidant enzyme monoamine oxidase (MAO) in the same region (Huang and Zhang, 2010)