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GPx1 deficiency increases sensitivity to H 2 O 2 induced ferroptosis Due to the decrease in GPx1 expression in CD macrophages, we hypothesized that this may contribute to the increased cytotoxicity observed in response to H 2 O 2

Dinculescu V, Ritter AC, dos Santos MP, Mohan RM, Schwarz BA, Lesiuk HJ, Lum C

On phase: 3 months of active dosing per cycle

Cauley DH, Atkinson BJ, Ng CS, Millikan RE, Xiao L, Corn PG, Jonasch E, Tannir NM

There has been substantial interest in exploring metabolic underpinnings of autism from the dual perspectives of yielding pathophysiologic insights and in discovering biomarkers for more precise treatment