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Zhijun Xie, Zhejiang Chinese Medical University, China Updates Copyright 2018 Li, Deng, Xie, Liu, Friedmann Angeli and Lai

It was known for many years that several electrophilic xenobiotics (e.g., phenacetin, acetaminophen, and N -hydroxy-2-acetylaminofluorene) are thiomethylated in vivo

They are usually found in the large intestine producing healthy short chain fatty acids - SCFA, and whose job is to break down vegetables/ starches

Cysteine starvation or xCT blockade confers the opposite result and increases cellular NADPH pools

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