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Deoxyadenosylcobalamin is a cofactor for methylmalonyl-CoA mutase, which catalyzes the conversion of methylmalonyl-CoA to succinyl-CoA in the mitochondria

High doses of vitamin B12 of up to 1,000 mcg are considered safe because the body will use the amount that it needs, and any excess will be flushed out through urine

Higher concentrations (3-4%+) are for experienced users who have established tolerance

Ice age animals include extinct species such as mammoths, woolly rhinoceroses, and cave bears (whose related gene sequence information is obtained through ancient DNA technology), as well as existing animals adapted to cold environments such as polar bears and reindeer

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