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Vitamin B12 is not naturally produced within the body, but must be either consumed with proper diet or supplemented via injection.

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It induces a diminution of CD4 + and CD8 + T cells by reducing early hematopoietic progenitor cells [70] and can inhibit directly CD3 + T cells proliferation as well as their cytotoxicity [71]

Another key point is the importance of integrating therapies