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Hyperglycemia-induced interactions between AGEs and their receptor, receptor for advanced glycation end products (RAGE), activate NF-B signaling in renal macrophages, thereby amplifying pro-inflammatory cytokines and chemokines that recruit monocytes to the kidney

A few examples of the detoxification role played by GSTs through their conjugation activity are as follows: Aflatoxin B1 Aflatoxins are harmful metabolites produced by several Aspergillus species

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Significantly overrepresented upregulated genes (Figure 2, red arrows) were found in 23 functional groups (Figure 2)