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Effect on intermittent hypoxia on plasma exosomal micro RNA signature and endothelial function in healthy adults

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Although YAP1 was overexpressed in mutated HPC cultured in 2D (with clear difference between the two mutated clones), YAP/TAZ and SOX9 were underexpressed in JAG1-mutated organoids, which well correlated with ductular paucity

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In addition, dual inhibition of PARP-1/2 and tankyrase 1/2 exhibited potent anticancer activity with strong synergy, suggesting an expanded therapeutic scope for PARP-1 inhibitors (149)