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Because glutathione is a protein (a tripeptide), your stomach is very good at breaking it down

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Exp Cell Res 220 : 232240 Cusack Jr JC, Liu R, Baldwin Jr AS (2000) Inducible chemoresistance to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) in colorectal cancer cells and a xenograft model is overcome by inhibition of nuclear factor-kappaB activation