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Okumus et al., 2013), both primary open and closed-angle glaucoma involve a complex and heterogeneous set of mechanisms, such as increased intraocular pressure (IOP), genetic mutation, decreased blood supply to the eye, neurotoxicity from increased ROS production, cell death, and phagocytosis (Fan Gaskin et al., 2021

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HIV-1 Tat-mediated microglial activation by impairing mitophagy/autophagy Mitophagy selectively removes damaged mitochondria through a progression from phagophore to autophagosome and then to lysosome, thereby preserving organelle integrity and cellular homeostasis [82]

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The gut microbiome is also essential for serotonin production, and gut microbes acting through short-chain fatty acids have been shown to modulate serotonin production in preclinical and in vitro human models [86]