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Proper handling is key

Similar to the findings of other studies in the STEP trial program 7,27 , exploratory outcomes showed that in the semaglutide group 80% of participants with prediabetes at baseline reverted to normoglycemia by the end of the trial (compared with 37% of those receiving placebo), while 99% of participants with normoglycemia at baseline maintained normoglycemia at the end of the trial (compared with 86% with placebo)

His framing is that methylation is foundational: if the body can't methylate efficiently, it can't detoxify, produce neurotransmitters, or repair DNA the way it's supposed to