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10.3389/fgene.2021.673002 32 Mazurek-MocholM.BonsmannT.MocholM.Poniewierska-BaranA.PawlikA

Mitochondria are also involved in apoptosis through the extrinsic pathway, in which the death-inducing signaling complex is formed, leading to activation of caspase-8 and then downstream caspases that target substrates leading to programmed cell death (Vakifahmetoglu-Norberg et al., 2017)