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To better define the impact of NQO1 transgenesis on physiological outcomes, we investigated 6-mo-old male NQO1-Tg mice and littermate controls (WT) that were fed either a standard laboratory diet (SD) or a high-fat diet (HFD, 60% kcal fat) ad libitum for periods up to 16 weeks (Fig

injections of 100 nmol kg 1 PYY analogue ( n = 7 mice and n = 6 cages), 100 nmol kg 1 PYYMK-801 ( n = 7 mice and n = 4 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 7 mice and n = 5 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 6 days

The heart is similar

Khan, C