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Male mice were used in all studies and sacrificed by exposure to carbon dioxide at different post-natal weeks: 8 (pre-symptomatic phase), 12 (disease onset), and 18 (late symptomatic phase) 18

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doi: 10.1093/ecco-jcc/jjad073 173 NordmannAJSuter-ZimmermannKBucherHCShaiITuttleKREstruchRet al

METALLURGY C07ORGANIC CHEMISTRY C07DHETEROCYCLIC COMPOUNDS C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom C07D215/04Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms C07D215/10Quaternary compounds CCHEMISTRY