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The human gastrointestinal tract harbors trillions of microorganisms, whose collective genome far exceeds the coding capacity of the human genome

doi: 10.1002/path.4906

In response to the dopaminergic neural activation induced by substances of abuse, such as heroin (119, 120), methamphetamine (121, 122), and cocaine (123), the mitochondrial respiratory chain is rapidly activated, leading to mitochondrial dysfunction, such as decreased mitochondrial membrane potential, mitochondrial DNA, and mitochondrial proteins, and increased cytochrome c release, resulting in increased ROS and oxidative stress (124)

Inhibition of lipid peroxidation during the reproductive period extends the lifespan of Caenorhabditis elegans