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Cell Mol Life Sci 76(20):41314144

Apolipoprotein E, a major risk factor for AD and a key regulator of lipoprotein metabolism was also upregulated in alcohol-treated APP/PS1 mice further supporting evidence of lipid dysregulation

Adams, Figure 1 Dysfunction of the UPS is associated with many neurological diseases including Alzheimers disease (AD), Amyotrophic Lateral Sclerosis (ALS), neuronal degeneration, remodeling and regeneration after spinal cord injury (SCI), Parkinsons disease (PD), Transmissible Spongiform Encephalopathies (TSE), and Huntingtons disease (HD