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181 : 16611672 Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X

ROS enhances inflammation by activating MAPK, which subsequently phosphorylates downstream proteins to upregulate the expression of pro-inflammatory genes such as IL-6, TNF-, and IL-1 [90]

Conclusions and future perspectives In conclusion, the multifaceted role of copper in atherosclerosis involves complex cellular and systemic metabolic processes

Among nonsteroidal anti-inflammatory drugs, aspirin dissociates mitochondrial-bound HK2 by disrupting its interaction with VDAC1, 1179 whereas diclofenac suppresses GLUT1 and HK2 activity, thus reducing glycolysis

Our observations suggest that pre-emptive genotyping of CYP2C9 and GSTM1 may aid in selection of more effective prophylaxis to reduce HC development in pediatric patients undergoing allogeneic HSCT