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Thus, the BBB has reduced trafficking during the active phase compared to other time points during the day, along with an increased morning surge in blood pressure contributing to a heightened prothrombotic state, increasing risk for ischemia

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1 Glaucomatous optic neurodegeneration 1.1 General concepts Glaucoma is a complex, chronic and multifactorial neurodegenerative pathology and is considered the leading cause of irreversible blindness (Weinreb et al., 2016

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