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Therefore, the aim of this study was twofold: 1) to assess vitamin B12 serum levels in ME/CFS patients before and after use of high dose vitamin B12 nasal drops and 2) to compare the changes in function before and after starting therapy, using an activity meter, the physical functioning score of the Rand 36 questionnaire, and both the fatigue and concentration scales of CIS20r questionnaire

This dose was chosen based on a previous dose-escalation study and subsequent work demonstrating its efficacy to drive weight loss in a short period of time 8

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To accurately landmark this site, practitioners need to fully expose the shoulder area, simply rolling up a sleeve of a shirt or jumper does not allow for an accurate view of the deltoid region for landmarking and may form a tourniquet and constrict blood supply