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Association of ACE2 receptor and ACEIs/ARBs with disease severity in COVID-19

In summary, the reprogramming of hepatocytes associated with a profibrotic milieu results in loss of mature parenchymal cells, characterized by loss of the master hepatocyte transcription factor HNF4 (158, 212) and upregulation of the developmental Notch, Hippo (213), and Hedgehog (214) signaling pathways

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Takeda T-A, Sasai M, Adachi Y, Ohnishi K, Fujisawa J-i, Izawa S, et al

The rash usually worsens significantly during the first one to two weeks before any improvement appears