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Under hyperglycemic conditions, upregulation of sorting nexin 9 (SNX9) triggers abnormal MDV production, transferring damaged mitochondrial components to recipient cells and impairing wound healing

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However, CHCHD2 KO had no effect on cellular sensitivity to treatment with Pac-1 ( Figure 6D ), consistent with previous work demonstrating that CHCHD2 regulates apoptosis upstream of procaspase-3 activity in the apoptotic cascade [19]