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Additional data from Japan and the U.S

Considering their association with many diseases, a large number of studies have investigated the presence and activity of antioxidant enzymes, the presence of their mRNA and deposits or their residual metabolites of OS reactions as indirect biomarkers of diseases (Marcozzi et al., 2003

The accompanying COA should be filed with experimental records to support reproducibility

Both NO and CO activate soluble-guanilyl cyclase (sGC), thus inducing and increase in intracellular cyclic-guanilyl monophosphate (cGMP) as second messenger [8, 9]