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Administration of CBD in the vmPFC of rats induced antidepressant effects, possibly via indirect activation of 5-HT1A receptors, suggesting that 5-HT1A receptors are involved in the in vivo effects of CBD (Russo et al., 2005)

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Although it is clear that IGF-IR confers resistance to molecularly targeted therapy, chemotherapy and radiotherapy, the complex IGF biology is a great challenge for targeting this pathway in cancer