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Konopleva M, Watt J, Contractor R, Tsao T, Harris D, Estrov Z, Bornmann W, Kantarjian H, Viallet J, Samudio I, Andreeff M

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In addition, the phosphorylation of 4E-BP1 and S6 kinase (downstream mTOR targets) was drastically reduced in the raptor and raptor/rictor mutants indicating mTORC1 activity is capable of regulating OL dynamics more than mTORC2 (Lebrun-Julien et al., Because mTOR has a major role in lipogenesis, it was postulated that mTORC1 could also be in part responsible for controlling proper lipid biosynthesis in adult myelinating OLs (Soliman, 2011