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Mainini F, Eccles MR (2020) Lipid and polymer-based nanoparticle siRNA delivery systems for cancer therapy

10.1128/aem.60.1.264-270.1994 Appl

When the gene doesnt contain the correct instructions (called a polymorphism mutation), a working enzyme is not produced and the body is unable to process folate into L methylfolate which is what the body is able to use and put to work