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Advancing research into the underlying mechanisms of perimenopausal depression is critical for detecting therapeutic targets and developing effective, targeted treatment approaches (Liang et al., 2024) (Figure 6)

In research, DSIP is sometimes studied in association with the Selank (GABAergic anxiolytic), theEpithalon (activation of telomerase and pineal melatonin), the Semax (nootropic neuropeptide) or the glutathione (antioxidant neuroprotection)

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Through protein degradation and a reduction in sulfur compounds, it generates hydrogen sulfide, which has antihypertensive effects [35] and seems to have overlapping actions with nitric oxide and prostaglandins, exerting many anti-inflammatory and antihypertensive effects [36]